Projects List

IIT Study at University Hospital Düsseldorf; the study aims to better understand the symptoms of spasticity through multimodal clinical and digital measurements and to longitudinally map these in affected patients undergoing treatment with medical cannabis.

A Prospective, Real-World Study Evaluating the Effectiveness of Risankizumab in Patients With Ulcerative Colitis

Non-interventional study (NIS) assessing the alteration of activity in ambulatory patients with CIS or RRMS under treatment of Glatiramer acetate 20mg/ml (Copaxone®); NIS Copaxone and activity

ALEMTL07122 - Nicht-interventionelle Langzeitstudie zur Beobachtung der Therapie mit LEMTRADA® bei aktiver, schubförmig remittierender MS; Lemtrada Risk Management Plan

Safety and Effectiveness of Ocrelizumab Under Real-World Conditions: A Non-Interventional Post-Authorization Safety Study in Patients Diagnosed With Relapsing or Primary Progressive Multiple Sclerosis – CONFIDENCE

Retrospective Investigation of Best Supportive and Medical Care in Clinical Practice in Patients With Primary Progressive Multiple Sclerosis (RETRO PPMS)

Evaluation of Specific Unmet Needs in Current Clinical Practice of Multiple Sclerosis: Characterization of Different Profiles of Relapsing-Remitting Multiple Sclerosis Patients Defined by Disease Activity and Patient-Reported Outcomes (PROFILE RRMS)

Retrospective chart review and historical comparison of Capmatinib vs. Standard of Care for German adult patients with locally advanced or metastatic NSCLC harboring METex14 mutations (RECAP)

CharacteriSation of Prescription patterns in Episodic and Chronic migraine patients starting Treatment in a Real life setting with Erenumab in Germany (SPECTRE)

Tracking the immune response to SARS-CoV-2 modRNA vaccines in an open-label multicenter study in participants with relapsing multiple sclerosis treated with ofatumumab s.c.

An open-label multicenter study to assess response to SARS-CoV-2 modRNA vaccines in participants with secondary progressive multiple sclerosis treated with Mayzent (siponimod)

Post-Authorization Non-interventional German treatment benefit study of GilEnyA in MS patients

Swiss study of the Impact of Mayzent (Siponimod) on secondary progressive multiple sclerosis patients in a long-term non-interventional study

Impact of Mayzent® (Siponimod) on secondary progressive multiple Sclerosis patients in a long-term non-Interventional study in Germany

A Non-interventional, multicenter, prospective observational study to evaluate patient related outcomes of Cladribine tablets in patients with Relapsing Multiple Sclerosis over two years

"Long term, prospective, observational cohort study evaluating the safety profile in patients with highly active relapsing multiple sclerosis (RMS) newly started on oral cladribine"

"Cladribine tablets –evaluation of Quality of Life (Studienarm Österreich)"

Cladribine tablets –evaluation of Quality of Life

"Cladribine tablets - Evaluation of therapy satisfaction"

Strategic project to ensure clinical vigilance and establish a quality standard as part of an overall treatment plan for therapy with natalizumab.

Research proposal for the SATURATE-MS study (“end of dose phenomena in Subcutaneous natalizumab treated MS patients”)

IIT Study at University Hospital Düsseldorf; the study aims to better understand the symptoms of spasticity through multimodal clinical and digital measurements and to longitudinally map these in affected patients undergoing treatment with medical cannabis.

IIT-Studie UK Düsseldorf

"Evaluation of digital remote monitoring of patients with Multiple Sclerosis (MS) using the MS Sherpa App In German: “Evaluation des digitalen Remote-Monitorings von Patienten mit Multipler Sklerose (MS) mittels MS Sherpa App”"

Federated Analysis is a collaborative analysis method while preserving privacy and data ownership. It allows e.g. statisticians to work with decentralized datasets without the need to transfer or share individual-level data

The DigiNet project aims to improve the care of patients with advanced non-small cell lung cancer by digitally connecting all treatment partners and patients. The project, which began on October 1, 2021, collects information on the implementation and effectiveness of therapies based on molecular findings, as well as patient well-being through questionnaires. By digitally linking regional hospitals, medical practices, and patients with specialized centers in two model regions, DigiNet facilitates the continuous management and evaluation of molecularly controlled therapies. A study will assess whether this enhanced approach to precision medicine improves patient survival and quality of life compared to standard care.

A phase 3 multicenter, randomised, prospective, open-label trial of fixed-duration (12 cycles) veneto-clax/ obinutuzumab vs. fixed-duration (15 cycles) venetoclax/ pirtobrutinib vs. MRD-guided ve-netoclax/ pirtobrutinib in patients with previously untreated chronic lymphocytic leukaemia (CLL)/ small lymphocytic lymphoma (SLL) aiming to establish measurement of individual residual disease for adjustment of treatment duration to improve outcomes, (CLL18 / MOIRAI trial of the GCLLSG)

Adherence behavior in the era of new therapeutic options for patients with multiple sclerosis

Treatment optimization using a multidimensional decision model (MSDM - Multiple Sclerosis Decision Modell zur Beurteilung des Therpaie- und Krankheitsverlaufs bei schubförmigfer MS)

A prospective, multicenter, non-interventional study to assess the use, effectiveness, and safety of ozanimod (Zeposia®) in the routine clinical treatment of patients with RRMS over a 5-year observation period.

Five-year, multicenter, prospective single-cohort, non-interventional study to document the use of Zinbryta® (daclizumab) in patients with relapsing multiple sclerosis (RMS) in clinical practice in Germany.

Subcutaneous: non-Interventional Study for Tysabri Patient Preference – Experience from Real World

TysabRi® Patient Management via a longitUdinal multi-dimensional STudy

Objective: To collect standardized magnetic resonance imaging (MRI) data as well as data obtained through the digital adaptation of the Multiple Sclerosis Functional Composite (MSFC — a test battery used to assess cognition, fine motor skills, and gait in MS patients) from patients diagnosed with multiple sclerosis or clinically isolated syndrome (CIS).

A phase III study testing the role of Proactive coaching on Patient Reported outcome in advanced or metastatic renal cell carcinoma treated with sunitinib